Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale
Identifieur interne : 002107 ( Main/Exploration ); précédent : 002106; suivant : 002108Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale
Auteurs : N C P. Cross [Royaume-Uni] ; H E White [Royaume-Uni] ; T. Ernst [Allemagne] ; L. Welden [Australie] ; C. Dietz [Allemagne] ; G. Saglio [Italie] ; F-X Mahon [France] ; C C Wong [États-Unis] ; D. Zheng [États-Unis] ; S. Wong [États-Unis] ; S-S Wang [États-Unis] ; S. Akiki [Royaume-Uni] ; F. Albano [Italie] ; H. Andrikovics [Hongrie] ; J. Anwar [Royaume-Uni] ; G. Balatzenko [Bulgarie] ; I. Bendit [Brésil] ; J. Beveridge [Australie] ; N. Boeckx [Belgique] ; N. Cerveira [Portugal] ; S-M Cheng [États-Unis] ; D. Colomer [Espagne] ; S. Czurda [Autriche] ; F. Daraio [Italie] ; S. Dulucq [France] ; L. Eggen [Norvège] ; H. El Housni [Belgique] ; G. Gerrard [Royaume-Uni] ; M. Gniot [Pologne] ; B. Izzo [Italie] ; D. Jacquin [États-Unis] ; J J W M. Janssen [Pays-Bas] ; S. Jeromin [Allemagne] ; T. Jurcek [République tchèque] ; D-W Kim [Corée du Sud] ; K. Machova-Polakova [République tchèque] ; J. Martinez-Lopez [Espagne] ; M. Mcbean [Australie] ; S. Mesanovic [Bosnie-Herzégovine] ; G. Mitterbauer-Hohendanner [Autriche] ; H. Mobtaker [États-Unis] ; M-J Mozziconacci [France] ; T. Paji [Slovénie] ; N. Pallisgaard [Danemark] ; P. Panagiotidis [Grèce] ; R D Press [États-Unis] ; Y-Z Qin [République populaire de Chine] ; J. Radich [États-Unis] ; T. Sacha [Pologne] ; T. Touloumenidou [Grèce] ; P. Waits [Royaume-Uni] ; E. Wilkinson [Royaume-Uni] ; R. Zadro [Croatie] ; M C Müller [Allemagne] ; A. Hochhaus [Allemagne] ; S. Branford [Australie]Source :
- Leukemia [ 0887-6924 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Fusion Proteins, bcr-abl.
- chemical , genetics : Proto-Oncogene Proteins c-bcr.
- chemical , standards : Fusion Proteins, bcr-abl.
- Calibration, Genes, abl, Humans, Polymerase Chain Reaction, Reference Standards, World Health Organization.
Abstract
Molecular monitoring of chronic myeloid leukemia patients using robust
Url:
DOI: 10.1038/leu.2016.90
PubMed: 27109508
PubMed Central: 5240017
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Bosnie-Herzégovine, Brésil, Bulgarie, Corée du Sud, Croatie, Danemark, Espagne, France, Grèce, Hongrie, Italie, Norvège, Pays-Bas, Pologne, Portugal, Royaume-Uni, République populaire de Chine, République tchèque, Slovénie, États-Unis
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<author><name sortKey="Cheng, S M" sort="Cheng, S M" uniqKey="Cheng S" first="S-M" last="Cheng">S-M Cheng</name>
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, San Juan Capistrano, CA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Colomer, D" sort="Colomer, D" uniqKey="Colomer D" first="D" last="Colomer">D. Colomer</name>
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</nlm:aff>
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<author><name sortKey="Daraio, F" sort="Daraio, F" uniqKey="Daraio F" first="F" last="Daraio">F. Daraio</name>
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</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Dulucq, S" sort="Dulucq, S" uniqKey="Dulucq S" first="S" last="Dulucq">S. Dulucq</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Eggen, L" sort="Eggen, L" uniqKey="Eggen L" first="L" last="Eggen">L. Eggen</name>
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</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="El Housni, H" sort="El Housni, H" uniqKey="El Housni H" first="H" last="El Housni">H. El Housni</name>
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</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Gerrard, G" sort="Gerrard, G" uniqKey="Gerrard G" first="G" last="Gerrard">G. Gerrard</name>
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<author><name sortKey="Gniot, M" sort="Gniot, M" uniqKey="Gniot M" first="M" last="Gniot">M. Gniot</name>
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</nlm:aff>
<country xml:lang="fr">Pologne</country>
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<author><name sortKey="Izzo, B" sort="Izzo, B" uniqKey="Izzo B" first="B" last="Izzo">B. Izzo</name>
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, Naples,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff30"><institution>CEINGE – Biotecnologie Avanzate</institution>
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</nlm:aff>
<country xml:lang="fr">Italie</country>
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<author><name sortKey="Jacquin, D" sort="Jacquin, D" uniqKey="Jacquin D" first="D" last="Jacquin">D. Jacquin</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Janssen, J J W M" sort="Janssen, J J W M" uniqKey="Janssen J" first="J J W M" last="Janssen">J J W M. Janssen</name>
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<country xml:lang="fr">Pays-Bas</country>
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<author><name sortKey="Jeromin, S" sort="Jeromin, S" uniqKey="Jeromin S" first="S" last="Jeromin">S. Jeromin</name>
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<author><name sortKey="Jurcek, T" sort="Jurcek, T" uniqKey="Jurcek T" first="T" last="Jurcek">T. Jurcek</name>
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<country xml:lang="fr">République tchèque</country>
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<author><name sortKey="Kim, D W" sort="Kim, D W" uniqKey="Kim D" first="D-W" last="Kim">D-W Kim</name>
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, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Machova Polakova, K" sort="Machova Polakova, K" uniqKey="Machova Polakova K" first="K" last="Machova-Polakova">K. Machova-Polakova</name>
<affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Molecular Genetics, Institute of Hematology and Blood Transfusion</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martinez Lopez, J" sort="Martinez Lopez, J" uniqKey="Martinez Lopez J" first="J" last="Martinez-Lopez">J. Martinez-Lopez</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Department of Hematology, Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Mcbean, M" sort="Mcbean, M" uniqKey="Mcbean M" first="M" last="Mcbean">M. Mcbean</name>
<affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Division of Cancer Medicine, Department of Pathology, Peter MacCallum Cancer Centre</institution>
, East Melbourne, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Mesanovic, S" sort="Mesanovic, S" uniqKey="Mesanovic S" first="S" last="Mesanovic">S. Mesanovic</name>
<affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Pathology Department, University Clinical Center Tuzla</institution>
, Tuzla,<country>Bosnia and Herzegovina</country>
</nlm:aff>
<country xml:lang="fr">Bosnie-Herzégovine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitterbauer Hohendanner, G" sort="Mitterbauer Hohendanner, G" uniqKey="Mitterbauer Hohendanner G" first="G" last="Mitterbauer-Hohendanner">G. Mitterbauer-Hohendanner</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Department of Laboratory Medicine, Division of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mobtaker, H" sort="Mobtaker, H" uniqKey="Mobtaker H" first="H" last="Mobtaker">H. Mobtaker</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Genoptix, Inc.</institution>
, Carlsbad, CA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mozziconacci, M J" sort="Mozziconacci, M J" uniqKey="Mozziconacci M" first="M-J" last="Mozziconacci">M-J Mozziconacci</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Departement de Biopathologie, Institut Paoli-Calmettes</institution>
, Marseille,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paji, T" sort="Paji, T" uniqKey="Paji T" first="T" last="Paji">T. Paji</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Specialized Haematology Laboratory, Department of Haematology, University Medical Centre Ljubljana</institution>
, Ljubljana,<country>Slovenia</country>
</nlm:aff>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pallisgaard, N" sort="Pallisgaard, N" uniqKey="Pallisgaard N" first="N" last="Pallisgaard">N. Pallisgaard</name>
<affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Department of Surgical Pathology, Zealand University Hospital</institution>
, Roskilde,<country>Denmark</country>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Panagiotidis, P" sort="Panagiotidis, P" uniqKey="Panagiotidis P" first="P" last="Panagiotidis">P. Panagiotidis</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Hematology Unit, First Department of Internal Medicine, Laiko Hospital, University of Athens,</institution>
Athens,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Press, R D" sort="Press, R D" uniqKey="Press R" first="R D" last="Press">R D Press</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Department of Pathology and Knight Cancer Institute, Oregon Health and Science University</institution>
, Portland, OR,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Qin, Y Z" sort="Qin, Y Z" uniqKey="Qin Y" first="Y-Z" last="Qin">Y-Z Qin</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Peking University People's Hospital, Peking University Institute of Hematology</institution>
, Beijing,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radich, J" sort="Radich, J" uniqKey="Radich J" first="J" last="Radich">J. Radich</name>
<affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Fred Hutchinson Cancer Research Center</institution>
, Seattle, WA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sacha, T" sort="Sacha, T" uniqKey="Sacha T" first="T" last="Sacha">T. Sacha</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Chair and Department of Hematology, Jagiellonian University</institution>
, Kraków,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Touloumenidou, T" sort="Touloumenidou, T" uniqKey="Touloumenidou T" first="T" last="Touloumenidou">T. Touloumenidou</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Laboratory of Molecular Biology, Hematology Department and HCT Unit, G. Papanicolaou Hospital</institution>
, Thessaloniki,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Waits, P" sort="Waits, P" uniqKey="Waits P" first="P" last="Waits">P. Waits</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Bristol Genetics Laboratory</institution>
, Bristol,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilkinson, E" sort="Wilkinson, E" uniqKey="Wilkinson E" first="E" last="Wilkinson">E. Wilkinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>HMDS, Leeds Teaching Hospitals</institution>
, Leeds,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zadro, R" sort="Zadro, R" uniqKey="Zadro R" first="R" last="Zadro">R. Zadro</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Faculty of Pharmacy and Biochemistry and University Hospital Center Zagreb, University of Zagreb</institution>
, Zagreb,<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>III. Medizinische Klinik, Medizinische Fakultät Mannheim, Universität Heidelberg</institution>
, Mannheim,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Hematology/Oncology, Universitätsklinikum Jena</institution>
, Jena,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Branford, S" sort="Branford, S" uniqKey="Branford S" first="S" last="Branford">S. Branford</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology</institution>
, Adelaide, SA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>School of Pharmacy and Medical Science, University of South Australia</institution>
, Adelaide, SA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>School of Medicine, University of Adelaide</institution>
, SA, Adelaide,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>School of Molecular and Biomedical Science, University of Adelaide</institution>
, Adelaide, SA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27109508</idno>
<idno type="pmc">5240017</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240017</idno>
<idno type="RBID">PMC:5240017</idno>
<idno type="doi">10.1038/leu.2016.90</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000727</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000727</idno>
<idno type="wicri:Area/Pmc/Curation">000726</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000726</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A21</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A21</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001995</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001995</idno>
<idno type="wicri:Area/PubMed/Curation">001971</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001971</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001971</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001971</idno>
<idno type="wicri:Area/Ncbi/Merge">003459</idno>
<idno type="wicri:Area/Ncbi/Curation">003459</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003459</idno>
<idno type="wicri:doubleKey">0887-6924:2016:Cross N:development:and:evaluation</idno>
<idno type="wicri:Area/Main/Merge">002106</idno>
<idno type="wicri:Area/Main/Curation">002107</idno>
<idno type="wicri:Area/Main/Exploration">002107</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Development and evaluation of a secondary reference panel for <italic>BCR-ABL1</italic>
quantification on the International Scale</title>
<author><name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust</institution>
, Salisbury,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>
, Southampton,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="White, H E" sort="White, H E" uniqKey="White H" first="H E" last="White">H E White</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust</institution>
, Salisbury,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Medicine, University of Southampton</institution>
, Southampton,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ernst, T" sort="Ernst, T" uniqKey="Ernst T" first="T" last="Ernst">T. Ernst</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Hematology/Oncology, Universitätsklinikum Jena</institution>
, Jena,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Welden, L" sort="Welden, L" uniqKey="Welden L" first="L" last="Welden">L. Welden</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology</institution>
, Adelaide, SA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dietz, C" sort="Dietz, C" uniqKey="Dietz C" first="C" last="Dietz">C. Dietz</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>III. Medizinische Klinik, Medizinische Fakultät Mannheim, Universität Heidelberg</institution>
, Mannheim,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Saglio, G" sort="Saglio, G" uniqKey="Saglio G" first="G" last="Saglio">G. Saglio</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin</institution>
, Orbassano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mahon, F X" sort="Mahon, F X" uniqKey="Mahon F" first="F-X" last="Mahon">F-X Mahon</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Bergonie Institute Cancer Center Bordeaux, INSERM U1218, University of Bordeaux</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wong, C C" sort="Wong, C C" uniqKey="Wong C" first="C C" last="Wong">C C Wong</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Novartis Pharmaceuticals Corporation</institution>
, East Hanover, NJ,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zheng, D" sort="Zheng, D" uniqKey="Zheng D" first="D" last="Zheng">D. Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Novartis Pharmaceuticals Corporation</institution>
, East Hanover, NJ,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wong, S" sort="Wong, S" uniqKey="Wong S" first="S" last="Wong">S. Wong</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Novartis Pharmaceuticals Corporation</institution>
, East Hanover, NJ,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, S S" sort="Wang, S S" uniqKey="Wang S" first="S-S" last="Wang">S-S Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Novartis Pharmaceuticals Corporation</institution>
, East Hanover, NJ,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Akiki, S" sort="Akiki, S" uniqKey="Akiki S" first="S" last="Akiki">S. Akiki</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>West Midlands Regional Genetics Laboratory</institution>
, Birmingham,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Albano, F" sort="Albano, F" uniqKey="Albano F" first="F" last="Albano">F. Albano</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Hematology, University of Bari</institution>
, Bari,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrikovics, H" sort="Andrikovics, H" uniqKey="Andrikovics H" first="H" last="Andrikovics">H. Andrikovics</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Laboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service</institution>
, Budapest,<country>Hungary</country>
</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Pathophysiology, Semmelweis University</institution>
, Budapest,<country>Hungary</country>
</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anwar, J" sort="Anwar, J" uniqKey="Anwar J" first="J" last="Anwar">J. Anwar</name>
<affiliation wicri:level="1"><nlm:aff id="aff13"><institution>King's College Hospital London</institution>
, London,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Balatzenko, G" sort="Balatzenko, G" uniqKey="Balatzenko G" first="G" last="Balatzenko">G. Balatzenko</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><institution>National Specialized Hospital for Active Treatment of Hematological Diseases</institution>
, Sofia,<country>Bulgaria</country>
</nlm:aff>
<country xml:lang="fr">Bulgarie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bendit, I" sort="Bendit, I" uniqKey="Bendit I" first="I" last="Bendit">I. Bendit</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Laboratorio de Biologia Tumoral, Disciplina de Hematologia do HC-FMUSP</institution>
, São Paulo,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beveridge, J" sort="Beveridge, J" uniqKey="Beveridge J" first="J" last="Beveridge">J. Beveridge</name>
<affiliation wicri:level="1"><nlm:aff id="aff16"><institution>PathWest Laboratory Medicine WA, Department of Haematology, Fiona Stanley Hospital</institution>
, Perth, WA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boeckx, N" sort="Boeckx, N" uniqKey="Boeckx N" first="N" last="Boeckx">N. Boeckx</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Laboratory Medicine, University Hospitals Leuven</institution>
, Leuven,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, KUL</institution>
, Leuven,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cerveira, N" sort="Cerveira, N" uniqKey="Cerveira N" first="N" last="Cerveira">N. Cerveira</name>
<affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Genetics, Portuguese Oncology Institute</institution>
, Porto,<country>Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cheng, S M" sort="Cheng, S M" uniqKey="Cheng S" first="S-M" last="Cheng">S-M Cheng</name>
<affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Department of Hematology and Oncology, Quest Diagnostics Nichols Institute</institution>
, San Juan Capistrano, CA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colomer, D" sort="Colomer, D" uniqKey="Colomer D" first="D" last="Colomer">D. Colomer</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Hematopathology Unit, Hospital Clinic, IDIBAPS</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Czurda, S" sort="Czurda, S" uniqKey="Czurda S" first="S" last="Czurda">S. Czurda</name>
<affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Division of Molecular Microbiology, Children's Cancer Research Institute</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Daraio, F" sort="Daraio, F" uniqKey="Daraio F" first="F" last="Daraio">F. Daraio</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin</institution>
, Orbassano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dulucq, S" sort="Dulucq, S" uniqKey="Dulucq S" first="S" last="Dulucq">S. Dulucq</name>
<affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Laboratoire Hematologie, Centre Hospitalier Universitaire de Bordeaux, Universite Bordeaux</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eggen, L" sort="Eggen, L" uniqKey="Eggen L" first="L" last="Eggen">L. Eggen</name>
<affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Laboratory of Molecular Pathology, Oslo University Hospital</institution>
, Oslo,<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="El Housni, H" sort="El Housni, H" uniqKey="El Housni H" first="H" last="El Housni">H. El Housni</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Clinique de Genetique Oncologique-Service de genetique, Hopital Erasme</institution>
, Brussels,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerrard, G" sort="Gerrard, G" uniqKey="Gerrard G" first="G" last="Gerrard">G. Gerrard</name>
<affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Imperial Molecular Pathology, Hammersmith Hospital</institution>
, London,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gniot, M" sort="Gniot, M" uniqKey="Gniot M" first="M" last="Gniot">M. Gniot</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences</institution>
, Poznan,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Izzo, B" sort="Izzo, B" uniqKey="Izzo B" first="B" last="Izzo">B. Izzo</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples</institution>
, Naples,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff30"><institution>CEINGE – Biotecnologie Avanzate</institution>
, Naples,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacquin, D" sort="Jacquin, D" uniqKey="Jacquin D" first="D" last="Jacquin">D. Jacquin</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Genoptix, Inc.</institution>
, Carlsbad, CA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Janssen, J J W M" sort="Janssen, J J W M" uniqKey="Janssen J" first="J J W M" last="Janssen">J J W M. Janssen</name>
<affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Department of Hematology and Molecular Diagnostics, VU University Medical Center</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jeromin, S" sort="Jeromin, S" uniqKey="Jeromin S" first="S" last="Jeromin">S. Jeromin</name>
<affiliation wicri:level="1"><nlm:aff id="aff33"><institution>MLL Munich Leukemia Laboratory</institution>
, Munich,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jurcek, T" sort="Jurcek, T" uniqKey="Jurcek T" first="T" last="Jurcek">T. Jurcek</name>
<affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno</institution>
, Brno,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, D W" sort="Kim, D W" uniqKey="Kim D" first="D-W" last="Kim">D-W Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Seoul St Mary's Hospital, Leukemia Research Institute, The Catholic University of Korea</institution>
, Seoul,<country>Korea</country>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Machova Polakova, K" sort="Machova Polakova, K" uniqKey="Machova Polakova K" first="K" last="Machova-Polakova">K. Machova-Polakova</name>
<affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Molecular Genetics, Institute of Hematology and Blood Transfusion</institution>
, Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martinez Lopez, J" sort="Martinez Lopez, J" uniqKey="Martinez Lopez J" first="J" last="Martinez-Lopez">J. Martinez-Lopez</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Department of Hematology, Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcbean, M" sort="Mcbean, M" uniqKey="Mcbean M" first="M" last="Mcbean">M. Mcbean</name>
<affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Division of Cancer Medicine, Department of Pathology, Peter MacCallum Cancer Centre</institution>
, East Melbourne, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mesanovic, S" sort="Mesanovic, S" uniqKey="Mesanovic S" first="S" last="Mesanovic">S. Mesanovic</name>
<affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Pathology Department, University Clinical Center Tuzla</institution>
, Tuzla,<country>Bosnia and Herzegovina</country>
</nlm:aff>
<country xml:lang="fr">Bosnie-Herzégovine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitterbauer Hohendanner, G" sort="Mitterbauer Hohendanner, G" uniqKey="Mitterbauer Hohendanner G" first="G" last="Mitterbauer-Hohendanner">G. Mitterbauer-Hohendanner</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Department of Laboratory Medicine, Division of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mobtaker, H" sort="Mobtaker, H" uniqKey="Mobtaker H" first="H" last="Mobtaker">H. Mobtaker</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Genoptix, Inc.</institution>
, Carlsbad, CA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mozziconacci, M J" sort="Mozziconacci, M J" uniqKey="Mozziconacci M" first="M-J" last="Mozziconacci">M-J Mozziconacci</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Departement de Biopathologie, Institut Paoli-Calmettes</institution>
, Marseille,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paji, T" sort="Paji, T" uniqKey="Paji T" first="T" last="Paji">T. Paji</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Specialized Haematology Laboratory, Department of Haematology, University Medical Centre Ljubljana</institution>
, Ljubljana,<country>Slovenia</country>
</nlm:aff>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pallisgaard, N" sort="Pallisgaard, N" uniqKey="Pallisgaard N" first="N" last="Pallisgaard">N. Pallisgaard</name>
<affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Department of Surgical Pathology, Zealand University Hospital</institution>
, Roskilde,<country>Denmark</country>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Panagiotidis, P" sort="Panagiotidis, P" uniqKey="Panagiotidis P" first="P" last="Panagiotidis">P. Panagiotidis</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Hematology Unit, First Department of Internal Medicine, Laiko Hospital, University of Athens,</institution>
Athens,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Press, R D" sort="Press, R D" uniqKey="Press R" first="R D" last="Press">R D Press</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Department of Pathology and Knight Cancer Institute, Oregon Health and Science University</institution>
, Portland, OR,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Qin, Y Z" sort="Qin, Y Z" uniqKey="Qin Y" first="Y-Z" last="Qin">Y-Z Qin</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Peking University People's Hospital, Peking University Institute of Hematology</institution>
, Beijing,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radich, J" sort="Radich, J" uniqKey="Radich J" first="J" last="Radich">J. Radich</name>
<affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Fred Hutchinson Cancer Research Center</institution>
, Seattle, WA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sacha, T" sort="Sacha, T" uniqKey="Sacha T" first="T" last="Sacha">T. Sacha</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Chair and Department of Hematology, Jagiellonian University</institution>
, Kraków,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Touloumenidou, T" sort="Touloumenidou, T" uniqKey="Touloumenidou T" first="T" last="Touloumenidou">T. Touloumenidou</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Laboratory of Molecular Biology, Hematology Department and HCT Unit, G. Papanicolaou Hospital</institution>
, Thessaloniki,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Waits, P" sort="Waits, P" uniqKey="Waits P" first="P" last="Waits">P. Waits</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Bristol Genetics Laboratory</institution>
, Bristol,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilkinson, E" sort="Wilkinson, E" uniqKey="Wilkinson E" first="E" last="Wilkinson">E. Wilkinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>HMDS, Leeds Teaching Hospitals</institution>
, Leeds,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zadro, R" sort="Zadro, R" uniqKey="Zadro R" first="R" last="Zadro">R. Zadro</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Faculty of Pharmacy and Biochemistry and University Hospital Center Zagreb, University of Zagreb</institution>
, Zagreb,<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>III. Medizinische Klinik, Medizinische Fakultät Mannheim, Universität Heidelberg</institution>
, Mannheim,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Hematology/Oncology, Universitätsklinikum Jena</institution>
, Jena,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Branford, S" sort="Branford, S" uniqKey="Branford S" first="S" last="Branford">S. Branford</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology</institution>
, Adelaide, SA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>School of Pharmacy and Medical Science, University of South Australia</institution>
, Adelaide, SA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>School of Medicine, University of Adelaide</institution>
, SA, Adelaide,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>School of Molecular and Biomedical Science, University of Adelaide</institution>
, Adelaide, SA,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Leukemia</title>
<idno type="ISSN">0887-6924</idno>
<idno type="eISSN">1476-5551</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calibration</term>
<term>Fusion Proteins, bcr-abl (analysis)</term>
<term>Fusion Proteins, bcr-abl (standards)</term>
<term>Genes, abl</term>
<term>Humans</term>
<term>Polymerase Chain Reaction</term>
<term>Proto-Oncogene Proteins c-bcr (genetics)</term>
<term>Reference Standards</term>
<term>World Health Organization</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Calibrage</term>
<term>Gènes abl</term>
<term>Humains</term>
<term>Normes de référence</term>
<term>Organisation mondiale de la santé</term>
<term>Protéines de fusion bcr-abl (analyse)</term>
<term>Protéines de fusion bcr-abl (normes)</term>
<term>Protéines proto-oncogènes c-bcr (génétique)</term>
<term>Réaction de polymérisation en chaîne</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fusion Proteins, bcr-abl</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proto-Oncogene Proteins c-bcr</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="standards" xml:lang="en"><term>Fusion Proteins, bcr-abl</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines de fusion bcr-abl</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines proto-oncogènes c-bcr</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Protéines de fusion bcr-abl</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Calibration</term>
<term>Genes, abl</term>
<term>Humans</term>
<term>Polymerase Chain Reaction</term>
<term>Reference Standards</term>
<term>World Health Organization</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Calibrage</term>
<term>Gènes abl</term>
<term>Humains</term>
<term>Normes de référence</term>
<term>Organisation mondiale de la santé</term>
<term>Réaction de polymérisation en chaîne</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><p>Molecular monitoring of chronic myeloid leukemia patients using robust <italic>BCR-ABL1</italic>
tests standardized to the International Scale (IS) is key to proper disease management, especially when treatment cessation is considered. Most laboratories currently use a time-consuming sample exchange process with reference laboratories for IS calibration. A World Health Organization (WHO) <italic>BCR-ABL1</italic>
reference panel was developed (MR<sup>1</sup>
–MR<sup>4</sup>
), but access to the material is limited. In this study, we describe the development of the first cell-based secondary reference panel that is traceable to and faithfully replicates the WHO panel, with an additional MR<sup>4.5</sup>
level. The secondary panel was calibrated to IS using digital PCR with <italic>ABL1</italic>
, <italic>BCR</italic>
and <italic>GUSB</italic>
as reference genes and evaluated by 44 laboratories worldwide. Interestingly, we found that >40% of <italic>BCR-ABL1</italic>
assays showed signs of inadequate optimization such as poor linearity and suboptimal PCR efficiency. Nonetheless, when optimized sample inputs were used, >60% demonstrated satisfactory IS accuracy, precision and/or MR<sup>4.5</sup>
sensitivity, and 58% obtained IS conversion factors from the secondary reference concordant with their current values. Correlation analysis indicated no significant alterations in %BCR-ABL1 results caused by different assay configurations. More assays achieved good precision and/or sensitivity than IS accuracy, indicating the need for better IS calibration mechanisms.</p>
</div>
</front>
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<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Belgique</li>
<li>Bosnie-Herzégovine</li>
<li>Brésil</li>
<li>Bulgarie</li>
<li>Corée du Sud</li>
<li>Croatie</li>
<li>Danemark</li>
<li>Espagne</li>
<li>France</li>
<li>Grèce</li>
<li>Hongrie</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Portugal</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
<li>République tchèque</li>
<li>Slovénie</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name>
</noRegion>
<name sortKey="Akiki, S" sort="Akiki, S" uniqKey="Akiki S" first="S" last="Akiki">S. Akiki</name>
<name sortKey="Anwar, J" sort="Anwar, J" uniqKey="Anwar J" first="J" last="Anwar">J. Anwar</name>
<name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name>
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